In situ monitoring of antibiotic susceptibility of bacterial biofilms in a microfluidic device
- Authors
- Kim, Keun Pil; Kim, Yun-Gon; Choi, Chang-Hyung; Kim, Hye-Eun; Lee, Sang-Ho; Chang, Woo-Suk; Lee, Chang-Soo
- Issue Date
- Dec-2010
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- LAB ON A CHIP, v.10, no.23, pp 3296 - 3299
- Pages
- 4
- Journal Title
- LAB ON A CHIP
- Volume
- 10
- Number
- 23
- Start Page
- 3296
- End Page
- 3299
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57443
- DOI
- 10.1039/c0lc00154f
- ISSN
- 1473-0197
1473-0189
- Abstract
- Antibiotic resistance of biofilms is a growing public health concern due to overuse and improper use of antibiotics. Thus, determining an effective minimal concentration of antibiotics to eradicate bacterial biofilms is crucial. Here we present a simple, novel one-pot assay for the analysis of antibiotic susceptibility of bacterial biofilms using a microfluidics system where continuous concentration gradients of antibiotics are generated. The results of minimal biofilm eradication concentration (MBEC) clearly confirm that the concentration required to eradicate biofilm-grown Pseudomonas aeruginosa is higher than the minimal inhibitory concentration (MIC) that has been widely used to determine the lowest concentration of antibiotics against planktonically grown bacteria.
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- Appears in
Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
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