Fracture Preventing Effects of Maxmarvil® Tablets (Alendronate 5 mg + Calcitriol 0.5 μg) in Patients with Osteoporosis
- Authors
- 유준일; 하용찬; 원예연; 양규현; 김상범; 유주형; 김동수
- Issue Date
- 2017
- Publisher
- 대한골대사학회
- Keywords
- Alendronate; Bone density; Calcitriol; Osteoporosis; Osteoporotic fractures
- Citation
- 대한골대사학회지, v.24, no.2, pp 91 - 96
- Pages
- 6
- Journal Title
- 대한골대사학회지
- Volume
- 24
- Number
- 2
- Start Page
- 91
- End Page
- 96
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/5760
- DOI
- 10.11005/jbm.2017.24.2.91
- ISSN
- 2287-6375
2287-7029
- Abstract
- Background: The purpose of this prospective, open-label, observational study was to assess the fracture preventing effect of Maxmarvil® tablets (alendronate 5 mg + calcitriol 0.5 μg) in patients with osteoporosis and to evaluate the change in bone mineral density (BMD) at the minimum 1-year follow-up. Methods: In this multicenter observational study, 691 patients with osteoporosis (aged 50 years or older) were treated with alendronate 5 mg + calcitriol 0.5 μg/day during their normal course of care. Patients were assessed at baseline and at 6 and 12 months. Baseline characteristics (including age, gender, concomitant disease, and baseline fractures) were evaluated. Results: From among the 848 participants, 149 individuals were lost to follow-up at the time of the study and 8 people had died. The 691 participants (54 men and 637 women) finished the follow-up study and completed the questionnaire. The mean age of the participants was 71.5 years (range, 50-92 years; mean age, 72.3 years for men and 71.4 years for women). Osteoporotic fracture occurred in 19 patients (2.7%). BMD of the lumbar spine and hip was improved by 5% and 1.5% at the latest follow-up. At the latest follow-up, 24 patients (3.5%) complained of drug-related complications such as dyspepsia, constipation, and nausea. Conclusions: This prospective observational study demonstrated that alendronate 5 mg + calcitriol 0.5 μg/day had a preventive effect on osteoporotic fracture and it increased the BMD of the lumbar spine by 5% at the latest follow-up.
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