Anti-inflammatory effects of two lupane-type triterpenes from leaves of Acanthopanax gracilistylus on LPS-induced RAW264.7 macrophages
- Authors
- Luo, J.; Li, X.-J.; Lee, G.-H.; Huang, J.-J.; Whang, W.-K.; Zhang, X.; Yook, C.-S.; Liu, X.-Q.
- Issue Date
- Nov-2021
- Publisher
- Sociedade Brasileira de Ciencia e Tecnologia de Alimentos, SBCTA
- Keywords
- Acanthopanax gracilistylus W.W. Smith; HMGB1; Lupane-type triterpenes; NF-κB; Proinflammatory cytokines; RAW 264.7 macrophages
- Citation
- Food Science and Technology (Brazil), v.42
- Journal Title
- Food Science and Technology (Brazil)
- Volume
- 42
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57707
- DOI
- 10.1590/fst.89721
- ISSN
- 0101-2061
1678-457X
- Abstract
- Acanthopanax gracilistylus W.W.Smith (AGS) is an traditional Chinese medicine and its leaves that have rich biological activities has been long used as a fresh vegetable in Chinese folk. There are two lupane-type triterpenoids, 3α,11α-dihydroxy-23-oxo-lup-20(29)-en-28-oic acid (1) and 3α,11α,23-trihydroxy-lup-20(29)-en-28-oic acid (2), were isolated as the active constituents from leaves of AGS. However, the anti-inflammatory effects and potential mechanisms of 1 and 2 on LPS-induced RAW264.7 Macrophages have not been evaluated. In this study, the results shown that compounds 1 and 2 reduced the levels of early proinflammatory cytokines TNF-α, IL-1β, the secretion of late pro-inflammatory cytokine HMGB1, as well as the activation of transcription factor NF-κB in RAW 264.7 macrophages induced by LPS. In conclusion, two lupane-type triterpenes (1 and 2) have anti-inflammatory activities in LPS-induced RAW264.7 cells through inhibiting expression of proinflammatory cytokines and NF‐κB activation and could be potentially used in treatment of inflammatory-related diseases in the future. © 2022, Sociedade Brasileira de Ciencia e Tecnologia de Alimentos, SBCTA. All rights reserved.
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