Type I Interferon Modulates the Battle of Host Immune System Against Virusesopen access
- Authors
- Seo, Young-Jin; Hahm, Bumsuk
- Issue Date
- Mar-2010
- Publisher
- ELSEVIER ACADEMIC PRESS INC
- Citation
- ADVANCES IN APPLIED MICROBIOLOGY, VOL 73, v.73, pp 83 - 101
- Pages
- 19
- Journal Title
- ADVANCES IN APPLIED MICROBIOLOGY, VOL 73
- Volume
- 73
- Start Page
- 83
- End Page
- 101
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57769
- DOI
- 10.1016/S0065-2164(10)73004-5
- ISSN
- 0065-2164
- Abstract
- Type I interferon (IFN), as its name implies, 'interferes' with virus replication by activating numerous genes. Further, virus-induced type I IFN regulates the magnitude and functions of cells directing the host immune system. Importantly, recent exploration into how type I IFN operates following virus infection has advanced our understanding of its role with respect to modulation of host innate and adaptive immune responses. Such activities include the activation of antigen-presenting dendritic cells and the localization, expansion or differentiation of virus-specific T lymphocytes and antibody-producing B lymphocytes. However, type I IFN not only benefits the host but can also induce unnecessary or extremely pathogenic immune responses. This review focuses on such interactions and the manner in which type I IFN induces dynamic changes in the host immune network, particularly adaptive immune responses to viral invasion. Manipulating the type I IFN-mediated host immune response during virus infections could provide new immunotherapeutic interventions to remedy viral diseases and implement more effective and sustainable type I IFN therapy.
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Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
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