Single metal-organic framework–embedded nanopit arrays: A new way to control neural stem cell differentiationopen access
- Authors
- Cho, Y.-W.; Jee, S.; Suhito, I.R.; Lee, J.-H.; Park, C.G.; Choi, K.M.; Kim, Tae-Hyung
- Issue Date
- Apr-2022
- Publisher
- American Association for the Advancement of Science
- Citation
- Science Advances, v.8, no.16
- Journal Title
- Science Advances
- Volume
- 8
- Number
- 16
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57810
- DOI
- 10.1126/sciadv.abj7736
- ISSN
- 2375-2548
2375-2548
- Abstract
- Stable and continuous supply of essential biomolecules is critical to mimic in vivo microenvironments wherein spontaneous generation of various cell types occurs. Here, we report a new platform that enables highly efficient neuronal cell generation of neural stem cells using single metal-organic framework (MOF) nanoparticle–embedded nanopit arrays (SMENA). By optimizing the physical parameters of homogeneous periodic nanopatterns, each nanopit can confine single nMOFs (UiO-67) that are specifically designed for long-term storage and release of retinoic acid (RA). The SMENA platform successfully inhibited physical interaction with cells, which contributed to remarkable stability of the nMOF (RA⊂UiO-67) structure without inducing nanoparticle-mediated toxicity issues. Owing to the continuous and long-term supply of RA, the neural stem cells showed enhanced mRNA expressions of various neurogenesis-related activities. The developed SMENA platform can be applied to other stem cell sources and differentiation lineages and is therefore useful for various stem cell–based regenerative therapies. Copyright © 2022 The Authors, some rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of ICT Engineering > School of Integrative Engineering > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57810)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.