Elastomeric polypentapeptides cross-linked into matrixes and fibers
- Authors
- Lee, Jonghwi; Macosko, Christopher W.; Urry, Dan W.
- Issue Date
- Mar-2001
- Publisher
- AMER CHEMICAL SOC
- Citation
- BIOMACROMOLECULES, v.2, no.1, pp 170 - 179
- Pages
- 10
- Journal Title
- BIOMACROMOLECULES
- Volume
- 2
- Number
- 1
- Start Page
- 170
- End Page
- 179
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57838
- DOI
- 10.1021/bm0000900
- ISSN
- 1525-7797
1526-4602
- Abstract
- Microbially prepared polypentapeptides were cross-linked by two chemical methods. In one chemical approach, (GVGIP)(260) where G = glycine, V = valine, I = isoleucine, and P = proline with no functional groups in its side chains, was cross-linked using dicumyl peroxide, and reaction conditions were systematically examined. Successful cross-linking was obtained even under Severe conditions for proteins, i.e., 3 h at 120 degreesC, without having significant side reactions. In the second chemical approach, two separate polymers, (GVGVP GVGVP GXGVP GVGVP GVGVP GVGVP)(n) where X is either E (the carboxylic, acid containing glutamic acid residue) or K (the lysine residue with an epsilon -amino function), were mixed and cross-linked using a carbodiimde reagent. The reaction temperature was found to affect the equilibrium swelling behavior of the resulting cross-linked hydrogels. In hydrogels cross-linked at a temperature above their hydrophobic folding and assembling transition temperature, 3D continuous filamentous microstructures were observed. Chemically cross-linked hydrogel fibers were also prepared and their anisotropy in swelling was confirmed. Uniaxial tensile moduli and equilibrium weight swelling ratios of the chemically cross-linked samples were compared to those of (GVGVP)(251) and (GVGIP)(260), gamma -irradiation cross-linked at different Mrad doses.
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