Tumor microenvironment-responsive histidine modified-hyaluronic acid-based MnO2 as in vivo MRI contrast agent
- Authors
- Hong, J.Y.; Lim, Y.G.; Song, Y.J.; Park, Kyeongsoon
- Issue Date
- Jan-2023
- Publisher
- Elsevier B.V.
- Keywords
- Hyaluronic acid; Manganese dioxide; T1 contrast agent
- Citation
- International Journal of Biological Macromolecules, v.226, pp 121 - 131
- Pages
- 11
- Journal Title
- International Journal of Biological Macromolecules
- Volume
- 226
- Start Page
- 121
- End Page
- 131
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/59905
- DOI
- 10.1016/j.ijbiomac.2022.12.033
- ISSN
- 0141-8130
1879-0003
- Abstract
- Tumor microenvironment (TME)-responsive manganese dioxide (MnO2) nanoparticles as a good T1 contrast agent could reduce unwanted toxicity and improve the accuracy of cancer detection. Despite these distinct advantages of MnO2-based nanoparticles, their synthesis involves multi-step processes with relatively long synthesis times. In this study, we synthesized histidine-modified hyaluronic acid (HA-His), and the prepared HA-His conjugates quickly reduce permanganate to MnO2, leading to facile production of HA-His/MnO2 nanoparticles with good water-dispersibility and stability under biological conditions. The synthesized HA-His/MnO2 nanoparticles readily responded to the TME (low pH, high H2O2, and high glutathione), and they were internalized into SCC7 cells with high CD44 expression. Moreover, the systemically administered HA-His/MnO2 nanoparticles with biocompatibility were specifically accumulated in tumor tissues, thereby efficiently enhancing T1 contrast in MRI. Therefore, the HA-His/MnO2 nanoparticles synthesized herein can be used as a promising T1 contrast agent for tumor MR imaging. © 2022 Elsevier B.V.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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