Plant-based natural flavonoids show strong inhibition of aflatoxin production and related gene expressions correlated with chemical structure
- Authors
- Tian, F.; Woo, S.Y.; Lee, S.Y.; Park, S.B.; Im, J.H.; Chun, Hyang Sook
- Issue Date
- Feb-2023
- Publisher
- Academic Press
- Keywords
- Aflatoxin; Aspergillus flavus; Flavonoids; Molecular modeling; Structure–activity relationship
- Citation
- Food Microbiology, v.109
- Journal Title
- Food Microbiology
- Volume
- 109
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/60399
- DOI
- 10.1016/j.fm.2022.104141
- ISSN
- 0740-0020
1095-9998
- Abstract
- Aflatoxins are strong carcinogenic and mutagenic fungal metabolites, and aflatoxin contamination is a critical issue in agriculture and food production. Natural flavonoids can suppress aflatoxin biosynthesis; however, the structure–activity relationship remains unclear. In the present study, a total of 36 structurally related natural flavonoids were tested against the aflatoxigenic Aspergillus flavus, both in-vitro and in-situ (on maize kernels), to investigate their structure–activity relationship and biological activity. Aflatoxin production (IC50 values: 10.85–20.09 μg/mL) and the expression of related genes (aflD, aflK, aflQ, and aflR) were found to be strongly inhibited. Structure–activity relationship studies revealed that the [–OH] or [–O–CH3] groups at position 6 of ring A and position 4′ of ring B were closely associated with antifungal and antiaflatoxigenic activities. These findings provide valuable information for the development of clean and safe methods to prevent aflatoxin contamination in food. © 2022 Elsevier Ltd
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/60399)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.