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Establishment of Reference Intervals of Cytokeratin 19 Fragment Antigen 21-1 in Korean Adultsopen access

Authors
Yoon, SumiLim, Yong KwanKim, Hye RyounLee, Mi-KyungKweon, Oh Joo
Issue Date
Jan-2023
Publisher
NLM (Medline)
Keywords
Adult; Age; CYFRA 21-1; Korean; Reference interval; Sex
Citation
Annals of laboratory medicine, v.43, no.1, pp 82 - 85
Pages
4
Journal Title
Annals of laboratory medicine
Volume
43
Number
1
Start Page
82
End Page
85
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/61117
DOI
10.3343/alm.2023.43.1.82
ISSN
2234-3806
2234-3814
Abstract
Cytokeratin 19 fragment antigen 21-1 (CYFRA 21-1) is useful for predicting and monitoring non-small cell lung cancer prognosis. We established reference intervals (RIs) of CYFRA 21-1 in Korean adults, including those older than 60 years. Data of 4,098 apparently healthy subjects (age range, 20-87 years) were analyzed after excluding those with a history of malignancy, high tumor marker concentrations (except CYFRA 21-1), and/or abnormal findings on a chest computed tomography scan through medical chart review. After removing two outliers, RIs of CYFRA 21-1 were determined using data of 4,096 subjects based on the non-parametric method (2.5th and 97.5th percentiles) according to CLSI guidelines EP28-A3c. The subjects were divided into two and four groups according to sex and age (20-40, 41-50, 51-60, and >60 years), respectively, and the median CYFRA 21-1 concentration was compared between the groups. The RI of CYFRA 21-1 was 0.66-3.84 ng/mL, applicable to both men and women. Regardless of sex, the CYFRA 21-1 concentration increased with age, suggesting that age-dependent RIs of CYFRA 21-1 should be applied. Rather than using a single RI provided by the manufacturer, the RI of CYFRA 21-1 should be continually verified and established in each clinical laboratory.
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의과대학 (의학부(임상-서울))
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