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Development of surface-enhanced Raman scattering-based immunoassay platforms using hollow Au nanostars for reliable SARS-CoV-2 diagnosis
- Authors
- Yu, Qian; Wu, Yixuan; Kang, Taejoon; Choo, Jaebum
- Issue Date
- Dec-2021
- Publisher
- John Wiley and Sons Inc
- Keywords
- hollow gold nanostar; immunoassay; magnetic bead; SARS-CoV-2; surface-enhanced Raman scattering
- Citation
- Bulletin of the Korean Chemical Society, v.42, no.12, pp 1699 - 1705
- Pages
- 7
- Journal Title
- Bulletin of the Korean Chemical Society
- Volume
- 42
- Number
- 12
- Start Page
- 1699
- End Page
- 1705
- ISSN
- 0253-2964
1229-5949
- Abstract
- We developed a novel surface-enhanced Raman scattering (SERS)-based SARS-CoV-2 assay platform using hollow Au nanostars to realize high-sensitivity diagnosis of SARS-CoV-2. The assay was performed using SARS-CoV-2 lysate as the target in a wide dynamic range with virus concentrations ranging from 0 to 104 PFU/ml and has a limit of detection (LOD) of 5.1 PFU/ml. This LOD value shows 100 times and 10 times better sensitivity compared to the LODs measured on the same sample using a commercially available rapid kit and enzyme-linked immunosorbent assay, respectively. Therefore, we believe that this SERS-based SARS-CoV-2 assay platform has high diagnostic accuracy for early or asymptomatic infected patients with low virus concentrations. Furthermore, the probability of a false-negative diagnosis is likely to be very low. © 2021 Korean Chemical Society, Seoul & Wiley-VCH GmbH
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