C-11-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer's disease in the absence of known mutations retains higher levels of PIB in the basal ganglia
- Authors
- Youn, Young Chul; Jang, Jae-Won; Han, Su-Hyun; Kim, HyeRyoun; Seok, Ju-Won; Byun, Jun Soo; Park, Kwang-Yeol; An, Seong Soo A.; Chun, In Kook; Kim, Sangyun
- Issue Date
- Jun-2017
- Publisher
- DOVE MEDICAL PRESS LTD
- Keywords
- Alzheimer's disease; early-onset Alzheimer's disease; amyloid PET; basal ganglia; Pittsburgh compound B; amyloid
- Citation
- CLINICAL INTERVENTIONS IN AGING, v.12, pp 1041 - 1048
- Pages
- 8
- Journal Title
- CLINICAL INTERVENTIONS IN AGING
- Volume
- 12
- Start Page
- 1041
- End Page
- 1048
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6247
- DOI
- 10.2147/CIA.S132884
- ISSN
- 1178-1998
1178-1998
- Abstract
- Purpose: Early-onset Alzheimer's disease (EOAD) has a different pathologic burden and clinical features compared with late-onset Alzheimer's disease(LOAD). We examined the effects of age at onset on the burden and distribution of beta-amyloid in patients with EOAD, in whom well-characterized mutations associated with Alzheimer's disease were absent. Methods: We genotyped ApoE, APP, PSEN1 and PSEN2 in the patients with Alzheimer's disease: 9 patients with EOAD (age <65), 11 with LOAD (age >70) and 8 normal controls (NCs), all of whom had undergone C-11-labeled Pittsburgh compound B-positron emission tomography imaging. Results: Patients with EOAD exhibited higher z scores and larger cluster sizes, and retained higher levels of Pittsburgh compound B in the bilateral thalamus and in some parts of the globus pallidus (P<0.05, false discovery rate). Conclusion: Distribution of amyloid deposition in EOAD outside the context of genetic mutations topographically showed some differences from that in LOAD.
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