Combined Impact of Telomere Length and Mitochondrial DNA Copy Number on Cognitive Function in Community-Dwelling Very Old Adults
- Authors
- Lee, Jee-Yon; Kim, Jung-Ha; Lee, Duk-Chul
- Issue Date
- 1-Nov-2017
- Publisher
- KARGER
- Keywords
- Telomere length; Cognitive decline; Mitochondrial DNA copy number; Very old adults; Aging
- Citation
- DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, v.44, no.3-4, pp 232 - 243
- Pages
- 12
- Journal Title
- DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Volume
- 44
- Number
- 3-4
- Start Page
- 232
- End Page
- 243
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6286
- DOI
- 10.1159/000480427
- ISSN
- 1420-8008
1421-9824
- Abstract
- Background: This study was conducted to investigate the combined impact of telomere length and mitochondrial DNA (mtDNA) copy number on cognitive function in community-dwelling very old adults. Methods: In total, 186 subjects over 75 years participated in this study. Cognitive function was assessed using the Korean Mini-Mental State Examination, and leukocyte telomere length and mtDNA copy number were measured using real-time polymerase chain reaction methods. Results: Both the fourth quartile of telomere length and mtDNA copy number were associated with cognitive dysfunction with an adjusted odds ratio of 0.23 (95% confidence interval (CI), 0.10-0.75) and 0.18 (95% CI, 0.03-0.54), respectively. Participants in the high telomere length/high mtDNA copy number group were more likely to have cognitive dysfunction than participants in the low telomere/low mtDNA copy number group with an adjusted odds ratio of 0.19 (95% CI, 0.07-0.58). Conclusion: Our results collectively suggest that the combination of telomere length and mtDNA copy number may be useful for monitoring cognitive decline in older adults. (C) 2017 S. Karger AG, Basel
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