Association between Inflammatory Biomarkers and Nutritional Status in Fatty Liveropen access
- Authors
- 임희숙; 최정윤; 이보라; 김상균; 김영석; 유정주
- Issue Date
- 2020
- Publisher
- 한국임상영양학회
- Keywords
- Non-alcoholic fatty liver disease; Adipokines; Adiponectin; Nutrients; Vitamin E
- Citation
- Clinical Nutrition Research, v.9, no.3, pp 182 - 194
- Pages
- 13
- Journal Title
- Clinical Nutrition Research
- Volume
- 9
- Number
- 3
- Start Page
- 182
- End Page
- 194
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/63597
- DOI
- 10.7762/cnr.2020.9.3.182
- ISSN
- 2287-3732
2287-3740
- Abstract
- The prevalence and progression of non-alcoholic fatty liver disease (NAFLD) is mediated via several factors correlating with hepatic necroinflammation (adipokines/cytokines). This study was performed to analyze the level of inflammatory markers according to the presence of NAFLD and to identify related nutritional factors. A total of 80 adults were classified into 2 groups (healthy and NAFLD), and their body composition, blood tests, and eating habits were evaluated. In addition, inflammatory markers (adiponectin, high-sensitivity C-reactive protein [CRP], and tumor necrosis factor-alpha [TNF-α]), nutrient intake status, and dietary quality were compared. The quality of diet was assessed according to the nutrient adequacy ratio and the mean adequacy ratio (MAR). The NAFLD group had a higher body mass index (p < 0.001) than the healthy group and also carried significantly higher CRP levels (p < 0.001) but lower adiponectin (p = 0.001). TNF-α levels increased significantly with fatty liver grade (p = 0.023). The NAFLD group showed significantly higher intake of energy, carbohydrates, iron, sodium, vitamin A and saturated fatty acids, but significantly lower intake of zinc and vitamin E than the healthy group. The MAR values were slightly higher in the NAFLD group but without any significant difference. The levels of adiponectin and vitamin E showed a significant inverse correlation (p < 0.05). Nutritional management of NAFLD patients is important, and the intake of antioxidant and anti-inflammatory nutrients such as zinc and vitamin E should be emphasized.
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Collections - College of Business & Economics > Department of Applied Statistics > 1. Journal Articles
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