Effect of Oral Administration of 3,3'-Diindolylmethane on Dextran Sodium Sulfate-Induced Acute Colitis in Mice
- Authors
- Jeon, Eun-Joo; Davaatseren, Munkhtugs; Hwang, Jin-Taek; Park, Jae Ho; Hur, Haeng Jeon; Lee, Ae Sin; Sung, Mi Jeong
- Issue Date
- Oct-2016
- Publisher
- AMER CHEMICAL SOC
- Keywords
- 3,3'-diindolylmethane; inflammatory bowel disease; dextran sodium sulfate; angiogenesis; lymphangiogenesis
- Citation
- JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.64, no.41, pp 7702 - 7709
- Pages
- 8
- Journal Title
- JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Volume
- 64
- Number
- 41
- Start Page
- 7702
- End Page
- 7709
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64150
- DOI
- 10.1021/acs.jafc.6b02604
- ISSN
- 0021-8561
1520-5118
- Abstract
- In patients with inflammatory bowel disease (IBD), inflammation is induced and maintained by lymphangiogenesis, and angiogenesis. 3,3'-Diindolylmethane (DIM) is a natural product formed in acidic conditions from indole-3-carbinol in cruciferous vegetables, and it is known for its chemotherapeutic activity. This study evaluated DIM's effects on angiogenesis, lymphangiogenesis, and inflammation in a mouse colitis model. Experimental colitis was induced in mice by administering 3% dextran sulfate sodium (DSS) via drinking water. DIM remarkably attenuated the clinical signs and histological characteristics in mice with DSS-induced colitis. DIM suppressed neutrophil infiltration and pro-inflammatory cytokines. Moreover, it significantly suppressed the expression of vascular endothelial growth factor (VEGF)-A and VEGF receptor (VEGFR)-2, indicating that the mechanism may be related to the repression of pro-angiogenesis activity. DIM also remarkably suppressed the expression of VEGF-C, VEGF-D, VEGFR-3, and angiopoietin-2; thus, the mechanism may also be related to the suppression of lymphangiogenesis. Therefore, DIM is a possible treatment option for inflammation of the intestine and associated angiogenesis and lymphangiogenesis
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Collections - Graduate School > Department of Food Science and Technology > 1. Journal Articles
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