Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design
- Authors
- Jun, Yun Ju; Lee, Jinhee; Hwang, Sehee; Kwak, Jung Hyun; Ahn, Hyeon Yeong; Bak, Youn Kyung; Koh, Jihoon; Lee, Jong Ho
- Issue Date
- Mar-2016
- Publisher
- BMC
- Keywords
- Xylose; Prediabetes; Postprandial hyperglycemia; Glucose
- Citation
- TRIALS, v.17, no.1
- Journal Title
- TRIALS
- Volume
- 17
- Number
- 1
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64320
- DOI
- 10.1186/s13063-016-1261-0
- ISSN
- 1745-6215
- Abstract
- Background: Previous studies have reported that xylose selectively inhibited the activity of sucrase. Xylose supplementation may have a beneficial effect on the postprandial glycemic response. However, no studies have investigated patients with IFG or the effectivity of a dose of D-xylose less than 10 % (w/w). Methods: The present study determined the effect of xylose consumption on postprandial hyperglycemia in normal (n = 25) and hyperglycemic subjects (n = 50). Subjects in this double-blind crossover design study were randomly assigned to consume a sucrose drink (Control, sucrose 50 g + deionized water 100 g) or a sucrose drink additionally containing 5 g (Test 1, sucrose: xylose = 10:1), 3.33 g (Test 2, sucrose: xylose = 15:1), or 2.5 g (Test 3, sucrose: xylose = 20:1) of D-xylose separated by a one-week interval. Results: Normal subjects in all test groups exhibited a significant decrease in serum glucose levels 15 min and 30 min after consuming the xylose-containing drinks compared to the control group. Significantly lower serum levels of insulin were observed at 15 min and 30 min after consuming the xylose-containing drinks compared to the control group. The test 1 group also exhibited a significantly lower insulin area under the curve than the control group. Hyperglycemic subjects (n = 50) in all test groups exhibited a significant decrease in serum glucose levels at 30 min compared to the control group. However, the test 1 group exhibited a significant increase in serum glucose levels at 120 min compared to the control group. Glucose-related markers did not significantly differ in each group. Conclusion: Xylose supplementation may exert a beneficial effect on postprandial glycemic responses in subjects with normal glucose levels and prediabetes.
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