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Photo-immobilization of bone morphogenetic protein-2 using azidophenyl gelatin on a collagen sheet enhances osteogenesis in a rat calvarial defect model
- Issue Date
- Aug-2016
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Azidophenyl gelatin; Az-Gel; Bone morphogenetic protein-2 (BMP-2); Osteogenesis; Photo-immobilization; Rat calvarial defect model
- Citation
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.40, pp 177 - 184
- Pages
- 8
- Journal Title
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
- Volume
- 40
- Start Page
- 177
- End Page
- 184
- ISSN
- 1226-086X
1876-794X
- Abstract
- Twenty-eight rats were randomized into two groups: a control group comprising a collagen sheet with only cast BMP-2; and an experimental group comprising a collagen sheet with BMP-2 photo immobilized using azidophenyl gelatin. Micro-computed tomography analysis revealed that there was more regenerated bone in experimental group at both 4 and 8 weeks. Immunohistochemical analysis revealed that the positively expressed cellular ratio in RUNX2-stained cells were significantly higher in experimental group. These results demonstrate that BMP-2 photo-immobilized using Az-Gel on a collagen sheet shows promising bone regeneration, and the sheet is a good candidate of BMP-2 carrier. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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