Development of a new tri-block copolymer with a functional end and its feasibility for treatment of metastatic breast cancer
- Authors
- Song, Ho-Taek; Hoang, Ngoc Ha; Yun, Jeong Min; Park, Young Jin; Song, Eun Hye; Lee, Eun Seong; Youn, Yu Seok; Oh, Kyung Taek
- Issue Date
- Aug-2016
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Metastasis; Nanomedicine; Tri-block copolymer; Animal imaging; Biocompatibility
- Citation
- COLLOIDS AND SURFACES B-BIOINTERFACES, v.144, pp 73 - 80
- Pages
- 8
- Journal Title
- COLLOIDS AND SURFACES B-BIOINTERFACES
- Volume
- 144
- Start Page
- 73
- End Page
- 80
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6651
- DOI
- 10.1016/j.colsurfb.2016.04.002
- ISSN
- 0927-7765
1873-4367
- Abstract
- We have developed nanomedicine vehicle based on a biocompatible tri-block copolymer, poly(ethylene glycol)-block-poly(lactic acid)-block-poly(ethylene glycol) (PEG-PLA-PEG) by simple approach without toxic linker to escalate therapeutic efficacy of anticancer agent by enhanced targeting to metastasized breast cancers. The synthesized ABA type copolymer had a low polydispersity index and formed small, highly stable spherical micelles. Furthermore, a functional group at the end site of the copolymer can be decorated with imaging agents and targeting moieties. The doxorubicin loaded micelles (DLM) showed higher drug-loading capacity, faster drug release, and better cell toxicity compared to those using di-block copolymers. DLM efficiently delivered to the metastatic breast cancers in brain and bone and suppressed growing of metastasis. In demonstration of treating metastasized animal model, we present a tri-block copolymer as. a potential nanomedicine vehicle to efficiently deliver anticancer drug and to effectively treat metastatic breast cancer. Crown Copyright (C) 2016 Published by Elsevier B.V. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6651)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.