자궁내막의 정상, 증식증 및 선암종에서의 Bcl-2 발현Bcl-2 Expression in Normal, Hyperplasia and Adenocarcinoma of Endometrium
- Authors
- 김미경; 유재형
- Issue Date
- Jun-1995
- Publisher
- INST MEDICAL SCIENCE
- Keywords
- normal endometriumn; cystic endometrial hyperplasia; endometrial adenocarcinoma; Bcl-2; immunohistochemistry
- Citation
- CHUNG-ANG JOURNAL OF MEDICINE, v.20, no.2, pp 147 - 154
- Pages
- 8
- Journal Title
- CHUNG-ANG JOURNAL OF MEDICINE
- Volume
- 20
- Number
- 2
- Start Page
- 147
- End Page
- 154
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/66586
- ISSN
- 0253-6250
- Abstract
- To evaluate the expression of Bcl-2, known as a candidate apoptosis suppressor gene, of normal and pathologic endometrial lesion, immunohistochemical studies were carried out by using avidin-biotin complex immunoperoxidase technique in paraffin embedded tissue sections from 50 cases.
This studies consisted of 6 cases of early proliferative endometrium, 9 cases of late proliferative endometrium, 5 cases of early secretory endometrium, 10 cases of late secretory endometrium, 10 cases of cystic endometrial hyperplasia and 10 cases of endometrile adenocarcinoma including 3 cases of well differentiated type, 2 cases of moderate differentiated type, 3 cases of poorly differentiated type and 2 cases of adenosquamous carcinoma.
The results were as follows;
1. Bcl-2 expression of proliferative endometrium was gradually increased from early proliferative phase to late proliferative phase.
2. Bcl-2 expression ofsecretory endoemtrium was loser than that of proliferative endometrium.
3. Bcl-2 expression of cystic endometrial hyperplasia was more heterogenous than that of proliferative endometrium.
4. Bcl-2 expression of endoemtrial adenocarcinoma depended upon the differentiation of cancer cell.
5. Therefore, authors suggested that Bcl-2 expression was associated with endometrial proliferation and carcinogenesis.
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