Inhibitory effects of 4-n-butylresorcinol on tyrosinase activity and melanin synthesisopen access
- Authors
- KIM, Dong-Seok; KIM, So-Young; PARK, Seo-Hyoung; CHOI, Yeong-Gon; KWON, a Sun-Bang; KIM, Myo-Kyoung; NA, Jung-Im; YOUN, Sang-Woong; PARK, Kyoung-Chan
- Issue Date
- Dec-2005
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- 4-n-butylresorcinol; melanogenesis; tyrosinase; microphthalmia-associated transcription factor (MITF)
- Citation
- BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.28, no.12, pp 2216 - 2219
- Pages
- 4
- Journal Title
- BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Volume
- 28
- Number
- 12
- Start Page
- 2216
- End Page
- 2219
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/66849
- DOI
- 10.1248/bpb.28.2216
- ISSN
- 0918-6158
1347-5215
- Abstract
- In this study, we investigated the effects of 4-n-butylresorcinol on melanogenesis in a spontaneously immortalized mouse melanocyte cell line, Mel-Ab. Our results show that 4-n-butylresorcinol significantly inhibits melanin synthesis in a concentration-dependent manner. In addition, it was also found to inhibit the activity of tyrosinase, the rate-limiting melanogenic enzyme. Several reports have indicated that the activation of extracellular signal-regulated kinase (ERK) or of Akt reduces melanin synthesis via microphthalmia-associated transcription factor (MITF) down-regulation. Accordingly, we examined the effects of 4-n-butylresorcinol on the ERK and Akt signaling pathways. 4-n-Butylresorcinol did not induce ERK, Akt activation, or MITF degradation, and had no effect on cAMP response element binding protein (CREB) phosphorylation, which stimulates MITF expression. In contrast, 4-n-butylresorcinol strongly reduced tyrosinase activity in a cell-free system. Moreover, 4-n-butylresorcinol showed an additive effect in combination with hinokitiol, which reduces MITF expression. These results show that the hypopigmentary effect of 4-n-butylresorcinol results from its direct inhibition of tyrosinase.
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