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Growth related secretion and production of GM-CSF by epithelial cell line

Authors
Park, Kyoung ChanKim, Dong SeokKim, Hye JinSeo, Koo IlKim, Kyu HanChung, Jin HoEun, Hee ChulJung, Hyun Chae
Issue Date
Jan-2001
Publisher
ELSEVIER SCI IRELAND LTD
Keywords
granulocyte-macrophage colony stimulating factor; wound healing; melanogenesis; keratinocytes
Citation
JOURNAL OF DERMATOLOGICAL SCIENCE, v.25, no.1, pp 53 - 58
Pages
6
Journal Title
JOURNAL OF DERMATOLOGICAL SCIENCE
Volume
25
Number
1
Start Page
53
End Page
58
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/66869
DOI
10.1016/S0923-1811(00)00111-0
ISSN
0923-1811
1873-569X
Abstract
Granulocyte-macrophage colony stimulating factor (GM-CSF) is a growth factor that supports the clonal development of normal granulocyte-macrophage progenitors. Especially in the skin, GM-CSF from keratinocytes may be a critical factor in the melanogenesis of the skin. In addition, GM-CSF is thought to play an important role in impaired wound healing. However, little is known regarding the synthesis and secretion of GM-CSF by keratinocytes of the skill. This investigation evaluated the effects of cell density on the production of GM-CSF by keratinocytes and the changes in the cell cycle. Interestingly, GM-CSF protein secretions and mRNA expressions were highly elevated in sub-confluent HaCat cells, and decreased in confluent state. In particular, GM-CSF production decreased in a density-dependent manner. We also found that the percentage of cells in the S phase of the cell cycle decreased markedly from 50 to 10%, when HaCat cells reached a confluent state. These results showed that GM-CSF synthesis and secretion by HaCat cells increases when cells are rapidly proliferating such as in the wound healing process. Thus, it might be said that GM-CSF produced by proliferating keratinocytes possibly contributes to wound healing and melanogenesis at the site of injury. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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