Effects of Dexamethasone on Endothelin-1(ET-1) Production by Keratinocytes
- Authors
- Lee, Il Whan; Lee, Seung Chul; Kim, Dong Seok; Kim, Hye Jin; Park, Kyoung Chan
- Issue Date
- Jul-2001
- Publisher
- 대한피부과학회
- Citation
- Annals of Dermatology, v.13, no.3, pp 148 - 152
- Pages
- 5
- Journal Title
- Annals of Dermatology
- Volume
- 13
- Number
- 3
- Start Page
- 148
- End Page
- 152
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/66881
- DOI
- 10.5021/ad.2001.13.3.148
- ISSN
- 1013-9087
2005-3894
- Abstract
- Epidermal keratinocytes are important sources of a wide variety of cytokines that include the endothelin-1 (ET-1). Glucocorticoids have been shown to inhibit the production of several cytokines. However, their effect on ET-1 synthesis by keratinocytes is still unknown. It has been reported that ultraviolet B (UVB) irradiation stimulates both the synthesis and release of ET-1 and it was observed that ET-1 secretion by HaCat cells increased with increasing UVB exposure. In this study, the effects of glucocorticoid on ET-1 production were evaluated using cultured HaCat keratinocytes. The results showed that dexamethasone suppressed basal re-lease of ET-1. In addition, it strongly inhibited the UVB-mediated augmentation of ET-1 production. Furthermore, lincomycin slightly enhanced the inhibitory effect of dexamethasone on ET-1 synthesis.
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