Gh: A GTP-Binding Protein with Transglutaminase Activity and Receptor Signaling Function
- Authors
- Nakaoka, Hideaki; Perez, Dianne M.; Baek, Kwang Jin; Das, Tanya; Husain, Ahsan; Misono, Kunio; Im, Mie-Jae; Graham, Robert M.
- Issue Date
- Jun-1994
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Citation
- SCIENCE, v.264, no.5165, pp 1593 - 1596
- Pages
- 4
- Journal Title
- SCIENCE
- Volume
- 264
- Number
- 5165
- Start Page
- 1593
- End Page
- 1596
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/66989
- DOI
- 10.1126/science.7911253
- ISSN
- 0036-8075
1095-9203
- Abstract
- The alpha(1)-adrenergic receptors activate a phospholipase C enzyme by coupling to members of the large molecular size (approximately 74 to 80 kilodaltons) G alpha(h) family of guanosine triphosphate (GTP)-binding proteins. Rat liver G alpha(h) is now shown to be a tissue transglutaminase type II (TGase II). The transglutaminase activity of rat liver TGase II expressed in COS-1 cells was inhibited by the nonhydrolyzable GTP analog guanosine 5'-O-(3-thiotriphosphate) or by alpha(1)-adrenergic receptor activation. Rat liver TGase II also mediated alpha(1)-adrenergic receptor stimulation of phospholipase C activity. Thus, G alpha(h) represents a new class of GTP-binding proteins that participate in receptor signaling and may be a component of a complex regulatory network in which receptor-stimulated GTP binding switches the function of G alpha(h) from transglutamination to receptor signaling.
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