유방의 침윤성 관암종에서 Rb 단백과 Ki-67 표지지수의 상관관계Correlation between Rb Protein Expression and Ki-67 Labelling Index in Invasive Ductal Carcinoma of the Breast
- Authors
- Han, Hong Kwon; Choi, Byung-Sun; Lee, Tae Jin; Park, Eon Sub; Yoo, Jae Hyung; Kim, Mi Kyung
- Issue Date
- 2002
- Publisher
- 중앙대학교 의과대학 의과학연구소
- Keywords
- Rb; Ki-67; Breast; Invasive ductal carcinoma
- Citation
- 중앙의대지, v.27, no.2, pp 63 - 68
- Pages
- 6
- Journal Title
- 중앙의대지
- Volume
- 27
- Number
- 2
- Start Page
- 63
- End Page
- 68
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/67045
- ISSN
- 0253-6250
- Abstract
- To evaluate correlations between clinicopthologic factors such as age, tumor size, histologic differentiation and lymph node metastasis, with expression of Rb protein and Ki-67, immunohistochemical study was done on 60 cases of invasive ductal carcinoma of the breast. Rb protein was expressed in 53.3%(32/60) of cases. Poorly differentiated tumors tends to show more increased expression of Rb protein(p=0.012). There was not significant difference according to patient age(p=0.068), tumor size (p=0.073)and lymph node metastasis(p=0.085). Ki-67 albeling index tended to be increased in tumors with large size(p=0.047), poor differentiation (p=0.016) or positive lymph node status(p=0.035). There was a significant correlation between Rb protein expression and Ki-67 labeling index (p=0.014). In conclusion, both Rb protein and Ki-67 labeling index significant reseverse correlation with histologic differentiation of the invasive ductal carcinoma of the breast. But the value of Rb proteinas prognostic factor remained to be studied.
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