Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3open access
- Authors
- Sung, Hyun Jea; Choi,Sun Mi; Yoon, Yoosik; An, Kyu Suk
- Issue Date
- Dec-1999
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- apoptosis; caspase-3; leukemia; Salvia miltiorrhiza BUNGE; tanshinone II-A
- Citation
- EXPERIMENTAL AND MOLECULAR MEDICINE, v.31, no.4, pp 174 - 178
- Pages
- 5
- Journal Title
- EXPERIMENTAL AND MOLECULAR MEDICINE
- Volume
- 31
- Number
- 4
- Start Page
- 174
- End Page
- 178
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/67069
- DOI
- 10.1038/emm.1999.28
- ISSN
- 1226-3613
2092-6413
- Abstract
- Tanshinone II-A is a derivative of phenanthrenequinone isolated from Salvia miltiorrhiza BUNGE, a traditional herbal medicine that is known to induce antiinflammatory, anti-oxidative and cytotoxic activity. We have examined cellular effects of Tanshione II-A on HL60 human promyelocytic leukemic cells and K562 human erythroleukemic cells. Tanshione II-A induced a dose- and time-dependent DNA fragmentation into the multiples of 180 bp and specific proteolytic cleavage of poly(ADP-ribose) polymerase in both cell lines. PI-staining and flow cytometry analysis of K562 cells following Tanshione II-A treatment showed an increase of the cells possessing hypodiploid DNA indicative of apoptotic state of cells. Caspase-3 activity was significantly increased during Tanshinone II-A treatment of both HL60 and K562 cells, whereas caspase-1 activity was not changed. These results suggest that Tanshione II-A induced HL60 and K562 cellular apoptosis that may be associated with the selective members of caspase family.
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