The effects of uncoupling protein 3 haplotypes on obesity phenotypes and very low-energy diet-induced changes among overweight Korean female subjects
- Authors
- Cha, Min Ho; Shin, Hyoung Doo; Kim, Kil Soo; Lee, Bong Hee; Yoon, Yoosik
- Issue Date
- May-2006
- Publisher
- W B SAUNDERS CO-ELSEVIER INC
- Citation
- METABOLISM-CLINICAL AND EXPERIMENTAL, v.55, no.5, pp 578 - 586
- Pages
- 9
- Journal Title
- METABOLISM-CLINICAL AND EXPERIMENTAL
- Volume
- 55
- Number
- 5
- Start Page
- 578
- End Page
- 586
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/67080
- DOI
- 10.1016/j.metabol.2005.11.012
- ISSN
- 0026-0495
1532-8600
- Abstract
- Responses to energy restriction tend to vary within the population because of genetic differences. In this study, we have genotyped 6 uncoupling protein 3 (UCP-3) polymorphisms (-55C/T, Int2-143G/C, Tyr99Tyr, Int3-47G/A, Int4-498C/T, and Tyr210Tyr) among 214 overweight Korean female subjects recruited from an obesity clinic. Three major haplotypes, identified with frequencies in excess of 0.04, were constructed from 6 single nucleotide polymorphisms. Association studies were then undertaken, involving the measurement of anthropometric characteristics and body composition both before and after I month of a energy-restriction regimen. At baseline, haplotype 1 (ht 1) [CGTACC] was associated with elevated anthropometric characteristics, including body weight, waist-hip ratio, and body mass index, as well as body components, including body fat mass and body fat-free mass. After the completion of the 1-month weight control program, which involved a very low-energy (2900 kJ/d) diet, we analyzed the outcomes according to the UCP-3 genetic polymorph isms. Among the 3 principal haplotypes, ht1 [CGTACC] was significantly associated with an increased reduction in body weight, in the codominant (P = .022), dominant (P = .016), and recessive (P = .041) models. Body mass index reduction was associated with the ht1 haplotype in a similar fashion. Among the body components, changes in body fat mass were significantly associated with ht1 [CGTACC] (P = .028), but changes in body fat-free mass were not significantly associated with the UCP-3 polymorphism. (c) 2006 Elsevier Inc. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/67080)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.