Combined vitamin C, hydrocortisone, and thiamine therapy for patients with severe pneumonia who were admitted to the intensive care unit: Propensity score-based analysis of a before-after cohort studyopen access
- Authors
- Kim, Won-Young; Jo, Eun-Jung; Eom, Jung Seop; Mok, Jeongha; Kim, Mi-Hyun; Kim, Ki Uk; Park, Hye-Kyung; Lee, Min Ki; Lee, Kwangha
- Issue Date
- Oct-2018
- Publisher
- W B SAUNDERS CO-ELSEVIER INC
- Keywords
- Ascorbic acid; Hydrocortisone; Intensive care unit; Pneumonia; Thiamine
- Citation
- JOURNAL OF CRITICAL CARE, v.47, pp 211 - 218
- Pages
- 8
- Journal Title
- JOURNAL OF CRITICAL CARE
- Volume
- 47
- Start Page
- 211
- End Page
- 218
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69450
- DOI
- 10.1016/j.jcrc.2018.07.004
- ISSN
- 0883-9441
1557-8615
- Abstract
- Purpose: To evaluate the efficacy of combined vitamin C, hydrocortisone, and thiamine in patients with severe pneumonia. Materials and methods: All consecutive patients with severe pneumonia who were treated with the vitamin C protocol (6 g of vitamin C per day) in June 2017-January 2018 (n = 53) were compared to all consecutive patients with severe pneumonia who were treated in June 2016-January 2017 (n = 46). Propensity score analysis was used to adjust for potential baseline differences between the groups. Results: In the propensity-matched cohort (n 36/group), the treated patients had significantly less hospital mortality than the control group (17% vs. 39%; P = 0.04). The vitamin C protocol associated independently with decreased mortality in propensity score-adjusted analysis (adjusted odds ratio = 0.15, 95% confidence interval = 0.04-0.56, P = 0.005). Relative to the control group, the treatment group had a significantly higher median improvement in the radiologic score at day 7 compared with baseline (4 vs. 2; P = 0.045). The vitamin C protocol did not increase the rates of acute kidney injury or superinfection. Conclusions: Combined vitamin C. hydrocortisone, and thiamine therapy may benefit patients with severe pneumonia. (C) 2018 The Authors. Published by Elsevier Inc.
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