Poorly Differentiated Clusters in Colorectal Adenocarcinomas Share Biological Similarities with Micropapillary Patterns as well as Tumor Budsopen access
- Authors
- Hong, Mineui; Kim, Jeong Won; Shin, Mi Kyung; Kim, Byung Chun
- Issue Date
- Oct-2017
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Colorectal Carcinoma; Poorly Differentiated Clusters; Tumor Budding; Micropapillary
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.32, no.10, pp 1595 - 1602
- Pages
- 8
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 32
- Number
- 10
- Start Page
- 1595
- End Page
- 1602
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69715
- DOI
- 10.3346/jkms.2017.32.10.1595
- ISSN
- 1011-8934
1598-6357
- Abstract
- In colorectal carcinoma, poorly differentiated clusters (PDCs) are a poor prognostic indicator and show morphological continuity and behavioral similarities to micropapillary patterns (MPPs) as well as tumor buds (TBs). Epithelial-mesenchymal transition (EMT) and inhibition of cancer-stromal interactions may contribute to the development of PDCs. To clarify the biological nature of PDCs, we examined immunohistochemical stainings for beta-catenin, Ki-67, E-cadherin, epithelial cell adhesion molecule (EpCAM), MUC1, and epithelial membrane antigen (EMA), which are associated with EMT and cancer-stromal interactions. The expression frequencies and patterns of PDCs, TBs, and differentiated neoplastic glands from the tumor center (TC) were compared. In the study group (117 cases), the nuclear beta-catenin staining index was higher in PDCs (37.3%) and TBs (43.3%) than in neoplastic glands from TC (8.9%, P < 0.001). The mean Ki-67 labeling index in TC was 71.5%, whereas it was decreased in PDCs (31.2%) and TBs (10.2%, P < 0.001). E-cadherin and EpCAM displayed a tendency to be found along the cell membrane in TC samples (91.5% and 92.3%, respectively), whereas they showed loss of membranous staining in PDC (44.4% and 36.8%, respectively) and TB samples (60.7% and 68.4%, respectively). An inside-out pattern for MUC1 and EMA was frequently observed in PDC (48.7% and 45.3%, respectively) and TB samples (46.2% and 45.3%, respectively), but not in TC samples. Our data demonstrate that there is a pathogenetic overlap among PDCs, TBs, and MPPs and suggest that they might represent sequential growth patterns that branch from common biological processes such as dedifferentiation and alteration in cancer-stromal interactions.
- Files in This Item
-
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69715)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.