Expression of Programmed Death Receptor Ligand 1 with High Tumor Infiltrating Lymphocytes Is Associated with Better Prognosis in Breast Canceropen access
- Authors
- Bae, Sang Byung; Cho, Hyun Deuk; Oh, Mee-Hye; Lee, Ji-Hye; Jang, Si-Hyong; Hong, Soon Auck; Cho, Junhun; Kim, Sung Yong; Han, Sun Wook; Lee, Jong Eun; Kim, Han Jo; Lee, Hyun Ju
- Issue Date
- Sep-2016
- Publisher
- KOREAN BREAST CANCER SOC
- Keywords
- Breast neoplasms; PD-L1; Prognosis; Tumor-infiltrating lymphocytes
- Citation
- JOURNAL OF BREAST CANCER, v.19, no.3, pp 242 - 251
- Pages
- 10
- Journal Title
- JOURNAL OF BREAST CANCER
- Volume
- 19
- Number
- 3
- Start Page
- 242
- End Page
- 251
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70535
- DOI
- 10.4048/jbc.2016.19.3.242
- ISSN
- 1738-6756
2092-9900
- Abstract
- Purpose: The interaction of programmed death receptor 1 (PD-1) and its ligand, programmed death receptor ligand 1 (PD-L1), negatively regulates immune responses. This study aimed to clarify PD-L1 expression levels in breast cancer through immunohistochemistry (IHC) and to evaluate associations between these findings and clinicopathologic variables, including prognosis. Methods: PD-L1 expression was analyzed using IHC on tissue microarrays of 465 invasive breast carcinomas. Results: High PD-L1 expression was demonstrated in 63 of 465 tumors (13.5%). High PD-L1 expression was significantly associated with high histologic grade (p<0.001), negative lymph nodes (p=0.011), early pathologic stage (p=0.025), high tumor-infiltrating lymphocyte (TIL) (p<0.001) counts, negative estrogen receptor (p<0.001) and progesterone receptor (p=0.002) expression, positive human epidermal growth factor receptor 2 (HER2) (p=0.003), cytokeratin 5/6 (p=0.011), epidermal growth factor receptor (p<0.001), and p53 (p<0.001) expression, and high Ki-67 proliferating index (p<0.001). Based on intrinsic subtypes, high PD-L1 expression and high TIL counts were significantly associated with the HER2 and triple-negative basal type (p<0.001). PD-L1 expression was significantly associated with better disease-free survival (DFS) (p=0.041) and overall survival (OS) (p=0.026) in the univariate analysis, but not in the multivariate analysis. Higher TIL levels was an independent prognostic factor for decreased disease progression (hazard ratio [HR], 2.389; 95% confidence interval [CI], 1.284-4.445; p=0.006) and overall death (HR, 3.666; 95% CI, 1.561-8.607; p=0.003). Conclusion: PD-L1 protein expression in breast cancer is associated with better DFS and OS, but is not an independent prognostic factor. High PD-L1 expression was significantly associated with high TIL levels. This finding has important implications for antibody therapies targeting the PD-1/PD-L1 signaling mechanism in breast cancer.
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