Relationship between polymorphisms near the IL28B gene and spontaneous HBsAg seroclearance: a systematic review and meta-analysis
- Authors
- Lee, D. H.; Lee, J. -H.; Kim, Y. J.; Park, N. H.; Cho, Y.; Lee, Y. B.; Yoo, J. -J.; Lee, M.; Cho, Y. Y.; Choi, W. -M.; Yu, S. J.; Yoon, J. -H.; Kim, C. Y.; Lee, H. -S.
- Issue Date
- Mar-2014
- Publisher
- WILEY
- Keywords
- hepatitis B surface antigen; hepatitis B virus; interleukin 28B; meta-analysis; polymorphism
- Citation
- JOURNAL OF VIRAL HEPATITIS, v.21, no.3, pp 163 - 170
- Pages
- 8
- Journal Title
- JOURNAL OF VIRAL HEPATITIS
- Volume
- 21
- Number
- 3
- Start Page
- 163
- End Page
- 170
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70848
- DOI
- 10.1111/jvh.12193
- ISSN
- 1352-0504
1365-2893
- Abstract
- Polymorphisms near the interleukin (IL) 28B gene have been proposed to be associated with spontaneous clearance of the hepatitis C virus. The purpose of this study was to assess the relationship between IL28B polymorphisms and the rate of spontaneous hepatitis B surface antigen (HBsAg) seroclearance by means of meta-analysis. MEDLINE/PubMed and EMBASE were utilized to identify relevant studies. Odds ratio (OR) and 95% confidence interval (CI) were analysed together to assess the strength of the association. Subgroup analyses were mainly performed according to ethnicity. A total of 4028 cases with persistent chronic hepatitis B and 2327 spontaneously recovered controls were included from 11 studies. The single nucleotide polymorphism (SNP), rs12979860, had no significant association with HBsAg seroclearance (OR=0.98, 95% CI: 0.84-1.14 in the dominant model; OR=1.00, 95% CI: 0.68-1.46 in the recessive model; and OR=0.95, 95% CI: 0.82-1.09 in the allelic model). The SNP, rs12980275, had no significant association either (OR=1.03, 95% CI: 0.84-1.26 in the dominant model; OR=1.17, 95% CI: 0.46-2.96 in the recessive model; and OR=1.04, 95% CI: 0.86-1.26 in the allelic model), nor did the SNP, rs8099917 (OR=0.94, 95% CI: 0.77-1.15 in the dominant model; OR=0.74, 95% CI: 0.34-1.62 in the recessive model; and OR=0.93, 95% CI: 0.77-1.13 in the allelic model). Similarly, the results of subgroup analyses by ethnicity also showed no association in either the Asian group or non-Asian group. We concluded that there was no significant association between common IL28B polymorphisms and the rate of spontaneous HBsAg seroclearance.
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