Reappraising the clinical usability of consolidation-to-tumor ratio on CT in clinical stage IA lung canceropen access
- Authors
- Yoon, Dong Woog; Kim, Chu Hyun; Hwang, Soohyun; Choi, Yoon-La; Cho, Jong Ho; Kim, Hong Kwan; Choi, Yong Soo; Kim, Jhingook; Shim, Young Mog; Shin, Sumin; Lee, Ho Yun
- Issue Date
- Jun-2022
- Publisher
- SPRINGER
- Keywords
- Lung cancer; Ground-glass opacity; Consolidation-to-tumor ratio; Prognosis
- Citation
- INSIGHTS INTO IMAGING, v.13, no.1
- Journal Title
- INSIGHTS INTO IMAGING
- Volume
- 13
- Number
- 1
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70923
- DOI
- 10.1186/s13244-022-01235-2
- ISSN
- 1869-4101
- Abstract
- Objectives Ground-glass opacity (GGO) on computed tomography is associated with prognosis in early-stage non-small cell lung cancer (NSCLC) patients. However, the stratification of the prognostic value of GGO is controversial. We aimed to evaluate clinicopathologic characteristics of early-stage NSCLC based on the consolidation-to-tumor ratio (CTR), conduct multi-pronged analysis, and stratify prognosis accordingly. Methods We retrospectively investigated 944 patients with clinical stage IA NSCLC, who underwent curative-intent lung resection between August 2018 and January 2020. The CTR was measured and used to categorize patients into six groups (1, 0%; 2, 0-25%; 3, 25-50%; 4, 50-75%; 5, 75-100%; and 6, 100%). Results Pathologic nodal upstaging was found in 1.8% (group 4), 9.0% (group 5), and 17.4% (group 6), respectively. The proportion of patients with a high grade of tumor-infiltrating lymphocytes tended to decrease as the CTR increased. In a subtype analysis of patients with adenocarcinoma, all of the patients with predominant micro-papillary patterns were in the CTR > 50% groups, and most of the patients with predominant solid patterns were in group 6 (47/50, 94%). The multivariate analysis demonstrated that CTR 75-100% (hazard ratio [HR], 3.85; 95% confidence interval [CI], 1.58-9.36) and CTR 100% (HR, 5.58; 95% CI, 2.45-12.72) were independent prognostic factors for DFS, regardless of tumor size. Conclusion We demonstrated that the CTR could provide various noninvasive clinicopathological information. A CTR of more than 75% is the factor associated with a poor prognosis and should be considered when making therapeutic plans for patients with early-stage NSCLC.
- Files in This Item
-
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70923)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.