Prognostic effect of sex according to shock severity in patients with acute myocardial infarction complicated by cardiogenic shockopen access
- Authors
- Kim, Yeji; Jang, Woo Jin; Park, Ik hyun; Oh, Ju Hyeon; Yang, Jeong Hoon; Gwon, Hyeon-Cheol; Ahn, Chul-Min; Yu, Cheol Woong; Kim, Hyun-Joong; Bae, Jang-Whan; Kwon, Sung Uk; Lee, Hyun-Jong; Lee, Wang Soo; Jeong, Jin-Ok; Park, Sang-Don
- Issue Date
- 2024
- Publisher
- Hellenic Cardiological Society
- Keywords
- Acute myocardial infarction; Cardiogenic shock; SCAI shock classification; Sex
- Citation
- Hellenic Journal of Cardiology
- Journal Title
- Hellenic Journal of Cardiology
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71214
- DOI
- 10.1016/j.hjc.2023.11.007
- ISSN
- 1109-9666
2241-5955
- Abstract
- Background: Sex disparities in cardiogenic shock (CS) treatment are controversial, and the prognostic implications of sex remain unclear in CS caused by acute myocardial infarction (AMI). Objectives: This study aimed to evaluate the prognostic effect of sex according to the severity of CS in patients undergoing percutaneous coronary intervention (PCI) for AMI complicated by CS. Methods: We assessed 695 patients from 12 tertiary centers in South Korea who underwent PCI for AMI complicated by CS, and analyzed outcomes by sex (female [n = 184] vs. male [n = 511]). We compared a 12-month patient-oriented composite endpoint (POCE, defined as a composite of all-cause mortality, myocardial infarction, re-hospitalization due to heart failure, and repeat revascularization) between the sexes, respective of SCAI shock stage C&D or E. Propensity score-matched analysis was performed to reduce bias. Results: We found that the female group was older and had higher vasoactive-inotropic and IABP-SHOCK II scores than the male group, with findings consistent across SCAI shock stages. During the 12-month follow-up period, multivariate analysis revealed no significant differences in POCE (HR 1.01, 95% CI 0.67–1.53, p = 0.963 for SCAI stage C&D, HR 1.24, 95% CI 0.84–1.84, p = 0.286 for SCAI stage E) between females and males. After propensity score matching, the incidence of POCE (HR 1.47, 95% CI 0.79–2.72, p = 0.220 for SCAI stage C&D, HR 0.88, 95% CI 0.49–1.57, p = 0.665 for SCAI stage E) was similar between sexes. Conclusions: Sex does not appear to influence the risk of 12-month POCE in patients treated with PCI for CS caused by AMI, irrespective of shock severity. Clinical Trial Registration: ClinicalTrials.gov NCT02985008. RESCUE (REtrospective and prospective observational Study to investigate Clinical oUtcomes and Efficacy of left ventricular assist device for Korean patients with cardiogenic shock), NCT02985008, Registered December 5, 2016 - retrospectively and prospectively. IRB Information: This study was approved by the institutional review board of Samsung Medical Center (Reference number: 2016-03-130). © 2023 Hellenic Society of Cardiology
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