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Prognostic effect of sex according to shock severity in patients with acute myocardial infarction complicated by cardiogenic shockopen access

Authors
Kim, YejiJang, Woo JinPark, Ik hyunOh, Ju HyeonYang, Jeong HoonGwon, Hyeon-CheolAhn, Chul-MinYu, Cheol WoongKim, Hyun-JoongBae, Jang-WhanKwon, Sung UkLee, Hyun-JongLee, Wang SooJeong, Jin-OkPark, Sang-Don
Issue Date
2024
Publisher
Hellenic Cardiological Society
Keywords
Acute myocardial infarction; Cardiogenic shock; SCAI shock classification; Sex
Citation
Hellenic Journal of Cardiology
Journal Title
Hellenic Journal of Cardiology
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71214
DOI
10.1016/j.hjc.2023.11.007
ISSN
1109-9666
2241-5955
Abstract
Background: Sex disparities in cardiogenic shock (CS) treatment are controversial, and the prognostic implications of sex remain unclear in CS caused by acute myocardial infarction (AMI). Objectives: This study aimed to evaluate the prognostic effect of sex according to the severity of CS in patients undergoing percutaneous coronary intervention (PCI) for AMI complicated by CS. Methods: We assessed 695 patients from 12 tertiary centers in South Korea who underwent PCI for AMI complicated by CS, and analyzed outcomes by sex (female [n = 184] vs. male [n = 511]). We compared a 12-month patient-oriented composite endpoint (POCE, defined as a composite of all-cause mortality, myocardial infarction, re-hospitalization due to heart failure, and repeat revascularization) between the sexes, respective of SCAI shock stage C&D or E. Propensity score-matched analysis was performed to reduce bias. Results: We found that the female group was older and had higher vasoactive-inotropic and IABP-SHOCK II scores than the male group, with findings consistent across SCAI shock stages. During the 12-month follow-up period, multivariate analysis revealed no significant differences in POCE (HR 1.01, 95% CI 0.67–1.53, p = 0.963 for SCAI stage C&D, HR 1.24, 95% CI 0.84–1.84, p = 0.286 for SCAI stage E) between females and males. After propensity score matching, the incidence of POCE (HR 1.47, 95% CI 0.79–2.72, p = 0.220 for SCAI stage C&D, HR 0.88, 95% CI 0.49–1.57, p = 0.665 for SCAI stage E) was similar between sexes. Conclusions: Sex does not appear to influence the risk of 12-month POCE in patients treated with PCI for CS caused by AMI, irrespective of shock severity. Clinical Trial Registration: ClinicalTrials.gov NCT02985008. RESCUE (REtrospective and prospective observational Study to investigate Clinical oUtcomes and Efficacy of left ventricular assist device for Korean patients with cardiogenic shock), NCT02985008, Registered December 5, 2016 - retrospectively and prospectively. IRB Information: This study was approved by the institutional review board of Samsung Medical Center (Reference number: 2016-03-130). © 2023 Hellenic Society of Cardiology
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