Effective wound healing on diabetic mice by adhesive antibacterial GNPs-lysine composited hydrogelopen access
- Authors
- Khunmanee, Sureerat; Choi, Anseo; Ahn, Il Young; Kim, Woo Ju; Bae, Tae Hui; Kang, Shin Hyuk; Park, Hansoo
- Issue Date
- Feb-2024
- Publisher
- Elsevier Inc.
- Keywords
- Bioengineering; Biomaterials; Biotechnology; Materials science
- Citation
- iScience, v.27, no.2
- Journal Title
- iScience
- Volume
- 27
- Number
- 2
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71829
- DOI
- 10.1016/j.isci.2024.108860
- ISSN
- 2589-0042
2589-0042
- Abstract
- Current trends in wound care research focus on creating dressings for diverse wound types, aiming to effectively control the wound healing process. We proposed a wound dressing composed of oxidized hyaluronic acid and amine gelatin with embedded lysine-modified gelatin nanoparticles (HGel-GNPs-lysine). This dressing improves mechanical properties and reduces degradation rates. The storage modulus for HGel-GNPs-lysine was 3,800 Pa, exceeding that of HGel (1,750 Pa). The positively charged surface of GNPs-lysine effectively eliminated Escherichia coli and Staphylococcus aureus. In a diabetic mice model (C57BL/6), HGel-GNPs-lysine immobilized with basic-fibroblast growth factor promoted granulation tissue thickness and collagen density. Gene expression analysis indicated that HGel-GNPs-lysine reduced inflammation and enhanced angiogenesis. This study highlights that HGel-GNPs-lysine could offer alternative treatment strategies for regulating the inflammatory response at the injury site in wound dressing applications. © 2024
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