Curcumin attenuates decline of CD69 expression on CD4+T cells and induces generation of CD25hiFoxp3+T cells through TGF-β1 production
- Authors
- Kim, Gi Rak; Jang, Mi Seon; Son, Young Min; Han, Seung Hyun; Yun, Cheol-Heui
- Issue Date
- Apr-2011
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Citation
- JOURNAL OF IMMUNOLOGY, v.186
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Volume
- 186
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72155
- DOI
- 10.4049/jimmunol.186.Supp.152.22
- ISSN
- 0022-1767
1550-6606
- Abstract
- Curcumin is a promising candidate as a natural medicinal agent to treat chronic inflammatory diseases. However, little is known about curcumin-mediated CD4+ T cell regulation, which contributes to the therapeutic effects of curcumin. Here, we report that curcumin inhibits T-cell receptor (TCR)-triggered immune responses of CD4+ T cells through suppression of proliferation, cytokine production and differentiation of CD4+ T cells. Intriguingly, spontaneous decline of CD69 expression was attenuated by curcumin treatment, which continued until 6 days of culture. We showed that curcumin-mediated CD69 up-regulation was dependent on extracellular signal-regulated kinase 1/2 (ERK1/2) signaling. Concomitantly, the expressions of C-C motif chemokine receptor 7 (CCR7), L-selectin and transforming growth factor-β1 (TGF-β1) were also increased. TGF-β1 production was moderate, but was high enough to lead to the late generation of CD25hiFoxp3+CD4+ T cells and to maintain prolonged suppression of CD4+ T cell activation. These findings suggest that the immunoregulatory role of curcumin is effective for CD4+ T cells.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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