Roles of Virtual Memory T Cells in Diseasesopen access
- Authors
- 석준; 조승동; 서성준; 박수형
- Issue Date
- Feb-2023
- Publisher
- 대한면역학회
- Keywords
- Virtual memory T cells; Infectious disease; Cancer
- Citation
- Immune Network, v.23, no.1, pp 1 - 11
- Pages
- 11
- Journal Title
- Immune Network
- Volume
- 23
- Number
- 1
- Start Page
- 1
- End Page
- 11
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72418
- DOI
- 10.4110/in.2023.23.e11
- ISSN
- 1598-2629
2092-6685
- Abstract
- Memory T cells that mediate fast and effective protection against reinfections are usually generated upon recognition on foreign Ags. However, a “memory-like” T-cell population, termed virtual memory T (TVM) cells that acquire a memory phenotype in the absence of foreign Ag, has been reported. Although, like innate cells, TVM cells reportedly play a role in first-line defense to bacterial or viral infections, their protective or pathological roles in immune-related diseases are largely unknown. In this review, we discuss the current understanding of TVM cells, focusing on their distinct characteristics, immunological properties, and roles in various immune-related diseases, such as infections and cancers.
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