The impact of sinusitis on the long-term clinical outcomes of asthmaopen access
- Authors
- Kim, Min-Hye; Jung, Jae-Woo; Cho, Sang-Heon; Min, Kyung-Up; Kang, Hye-Ryun
- Issue Date
- Oct-2014
- Publisher
- Asia Pacific Association of Allergy, Asthma and Clinical Immunology
- Keywords
- Asthma; Disease progression; Forced expiratory volume; Sinusitis
- Citation
- Asia Pacific allergy, v.4, no.4, pp 222 - 229
- Pages
- 8
- Journal Title
- Asia Pacific allergy
- Volume
- 4
- Number
- 4
- Start Page
- 222
- End Page
- 229
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/73223
- DOI
- 10.5415/apallergy.2014.4.4.222
- ISSN
- 2233-8276
- Abstract
- BACKGROUND: Upper respiratory diseases have been linked with lower respiratory diseases. However, the long-term effect of sinusitis on the clinical outcomes of asthma has not been fully evaluated. OBJECTIVE: The aim of this study was to investigate the impact of sinusitis on the disease progression of asthma. METHODS: Seventy-five asthmatic patients confirmed with the methacholine bronchial provocation test or bronchodilator response were included. The study patients underwent paranasal sinus x-ray upon their asthma evaluation and they visited the hospital at least 3 years or longer. We retrospectively reviewed their medical records and compared data according to the presence of comorbid sinusitis. RESULTS: Among the 75 asthmatic subjects, 38 subjects (50.7%) had radiologic evidence of sinusitis. Asthmatics with sinusitis had significantly lower forced expiratory volume in 1 second (FEV1; 79.2% vs. 88.2%) and PC20 values (5.2 mg/mL vs. 8.9 mg/mL) compared to asthmatics without sinusitis at the time of diagnosis. This difference in FEV1 disappeared (82.6% vs. 87.2%) in the 3-year follow-up, although FEV1 was more variable (31.7% vs. 23.5%) and worst FEV1 was also significantly lower in patients with sinusitis compared to those without (70.9% vs. 79.0%). There were no significant differences in the number of hospital visits, acute exacerbations, and scores for the asthma control test. CONCLUSIONS: Although sinusitis was associated with lower baseline lung function and higher hyperreactivity, sinusitis was not related with significant deterioration in lung function over 3 years of follow-up. Asthmatics with sinusitis showed more variability in lung function during the follow-up period. Healthcare utilization was not different except antibiotics use.
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