A Randomized Controlled Trial of Thermo-Sensitive Sol-Gel Anti-Adhesion Agent after Gynecologic Surgeryopen access
- Authors
- Kim, Young Im; Lee, Maria; Kim, Se Ik; Seol, Aeran; Lee, Eun Ji; Kim, Hee Seung; Song, Yong Sang
- Issue Date
- Jul-2020
- Publisher
- MDPI
- Keywords
- abdominal adhesion; gynecologic surgery; anti-adhesion agent; thermo-sensitive agent; sol-gel process
- Citation
- JOURNAL OF CLINICAL MEDICINE, v.9, no.7
- Journal Title
- JOURNAL OF CLINICAL MEDICINE
- Volume
- 9
- Number
- 7
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/74160
- DOI
- 10.3390/jcm9072261
- ISSN
- 2077-0383
- Abstract
- Postoperative abdominal adhesions can lead to several adverse consequences such as pelvic pain, bowel obstruction, and infertility. We aimed to explore the anti-adhesion efficacy and safety of a thermo-sensitive sol-gel agent in patients who receive abdominopelvic surgery for benign gynecologic disease. This study was a randomized, controlled, single-blind clinical trial of women undergoing benign gynecologic surgery between January 2017 and December 2017. The patients were randomly assigned to three groups with a 1:1:1 ratio: experimental group (received the thermo-sensitive sol-gel agent), control group (untreated), and comparator group (received 4% icodextrin). Patients were followed for 4 weeks postoperatively, and efficacy was evaluated by performing the visceral slide test to identify adhesion formation. In total, 183 patients were enrolled in the study, and 178 (97.3%) completed the trial. The incidence rate of abdominal adhesion formation was significantly lower in the experimental group than in the control group (7.9% vs. 21.1%,p= 0.040); however, it was similar between the experimental and comparator groups (7.9% vs. 13.8%.p= 0.299). At 4 weeks, no differences in adhesion-related symptoms were observed between the experimental and control groups. Adverse events were mostly mild and did not differ significantly among the three groups (p= 0.375). In conclusion, use of a thermo-sensitive sol-gel agent was safe and effective to prevent abdominal adhesions after benign gynecologic surgeries.
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