Serum Preadipocyte Factor 1 Levels Are Not Associated with Bone Mineral Density among Healthy Postmenopausal Korean Womenopen access
- Authors
- Choi, Hoon Sung; Kim, Sang-Wook; Cho, Eun-Hee
- Issue Date
- Mar-2017
- Publisher
- KOREAN ENDOCRINE SOC
- Keywords
- Preadipocyte factor 1; Postmenopausal women; Bone density; Osteoporosis
- Citation
- ENDOCRINOLOGY AND METABOLISM, v.32, no.1, pp 124 - 128
- Pages
- 5
- Journal Title
- ENDOCRINOLOGY AND METABOLISM
- Volume
- 32
- Number
- 1
- Start Page
- 124
- End Page
- 128
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/74487
- DOI
- 10.3803/EnM.2017.32.1.124
- ISSN
- 2093-596X
2093-5978
- Abstract
- Background: Multipotent mesenchymal stem cells can differentiate into adipocytes or osteoblasts through closely regulated lineagecontrol processes. However, adipocyte precursor cells release preadipocyte factor 1 (Pref-1), which inhibits the differentiation of mesenchymal stem cells into mature adipocytes and osteoblasts. Previous studies have also reported an inverse association between Pref-1 levels and bone mineral density (BMD) among patients with anorexia nervosa. Methods: In this retrospective study, we examined the correlations between Pref-1 levels and BMD among 124 healthy postmenopausal women (>50 years old). The patients had provided information regarding their clinical characteristics, and underwent blood testing and serum Pref-1 testing. Results: The subjects' mean age was 59.9 +/- 7.1 years and the median time since menopause onset was 9.1 years. A history of osteoporotic fracture was identified in 23 subjects (19%). Serum Pref-1 levels were not significantly correlated with BMD values at the lumbar spine (R-2=0.038, P=0.109), femur neck (R-2=0.017, P=0.869), and total hip (R-2=0.041, P=0.09), and multivariate analyses with adjustment for age and body mass index also did not detect any significant correlations. Subgroup analyses according to a history of fracture also did not detect significant associations between Pref-1 levels and BMD values. Conclusion: In our study population, it does not appear that serum Pref-1 levels are significantly associated with BMD values and osteoporosis.
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