Liver-Wrapping, Nitric Oxide-Releasing Nanofiber Downregulates Cleaved Caspase-3 and Bax Expression on Rat Hepatic Ischemia-Reperfusion Injury
- Authors
- Ko, H. M.; Joo, S. H.; Jo, J. H.; Park, W. S.; Jung, W. Y.; Shin, J. H.; Ahn, H. J.
- Issue Date
- Jun-2017
- Publisher
- ELSEVIER SCIENCE INC
- Citation
- TRANSPLANTATION PROCEEDINGS, v.49, no.5, pp 1170 - 1174
- Pages
- 5
- Journal Title
- TRANSPLANTATION PROCEEDINGS
- Volume
- 49
- Number
- 5
- Start Page
- 1170
- End Page
- 1174
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/74639
- DOI
- 10.1016/j.transproceed.2017.03.054
- ISSN
- 0041-1345
1873-2623
- Abstract
- Background. Hepatic ischemia-reperfusion injury (IRI) is an important determinant of the outcome of hepatic surgery, including re-section and transplantation. Previous studies have shown that nitric oxide (NO) has a protective effect against IRI. Therefore, many studies have examined methods for supplying NO. In this study, we investigated the effect of NO-releasing nanofibers on hepatic IRI in a rat model. Methods. Male Sprague-Dawley rats were divided into 4 groups: control, IRI only (n = 3); group 1, hepatic IRI and liver-wrapping with nanofiber lacking NO (n = 4); group 2, hepatic IRI and liver-wrapping with NO rapid-releasing nanofiber (n = 4); and group 3, hepatic IRI and liver-wrapping with NO slow-releasing nanofiber (n = 5). Results. The levels of aspartate aminotransferase and alanine aminotransferase were not significantly different between groups. On the basis of Western blots, Bax/beta-actin levels were significantly lower in group 2 than in group 3 (P < .01). Cleaved Caspase-3/beta-actin levels were significantly lower in group 2 than in the control, group 1, and group 3 (P < .05,.01, and .01, respectively). However, there were no significant differences in Bcl-2/beta-actin between groups. Conclusions. The liver-wrapping NO rapid-releasing nanofiber downregulated cleaved Caspase-3 and Bax expression. It has a protective effect by reducing apoptosis in hepatic IRI in rats.
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