Inhibitory Effect of Standardized Curcuma xanthorrhiza Supercritical Extract on LPS-Induced Periodontitis in Rats
- Authors
- Kook, Kyo Eun; Kim, Changhee; Kang, Wonku; Hwang, Jae-Kwan
- Issue Date
- Oct-2018
- Publisher
- KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
- Keywords
- Curcuma xanthorrhiza; osteoblastogenesis; osteoclastogenesis; periodontitis; periodontal inflammation
- Citation
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.28, no.10, pp 1614 - 1625
- Pages
- 12
- Journal Title
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
- Volume
- 28
- Number
- 10
- Start Page
- 1614
- End Page
- 1625
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/747
- DOI
- 10.4014/jmb.1808.08052
- ISSN
- 1017-7825
1738-8872
- Abstract
- Periodontitis, which is a severe inflammatory disease caused by endotoxins secreted from oral pathogens, destructs gingival tissue and alveolar bone. Curcuma xanthorrhiza, commonly called Java turmeric, has been shown to possess anti-bacterial and anti-inflammatory activities. The present study evaluated the inhibitory effect of C. xanthorrhiza supercritical extract (CXS) standardized with xanthorrhizol on lipopolysaccharide (LPS)-induced periodontitis in an animal model. LPS was topically injected into the periodontium of Sprague-Dawley rats to induce periodontitis and CXS (30 and 100 mg.kg(-1).day(-1)) was orally administered after day 12. Histologically, CXS inhibited the collapse of gingival tissue by preventing cell infiltration. CXS significantly downregulated the expression of matrix metalloproteases (MMPs) and inflammation-related biomarkers, such as nuclear factor-kappa B (NF-kappa B) and interleukin-1 beta (IL-1 beta) in gingival tissue. CXS also improved bone remodeling by downregulating osteoclastic transcription factors, such as nuclear factor of activated T-cells c1 (NFATc1), tartrate-resistant acid phosphatase (TRAP), and cathepsin K. In addition, CXS upregulated osteoblast differentiation-related markers, alkaline phosphate (ALP) and collagen type I alpha (COLA1). Thus, CXS can ameliorate periodontitis by inhibiting inflammation and improving bone remodeling.
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