Visible-Light-Promoted Synthesis of Fluoroalkylated Oximes
- Authors
- Lee, Da Seul; Hwang, Ho Seong; Cho, Eun Jin
- Issue Date
- Sep-2018
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- fluorine; nitrites; oximes; photocatalysis; radical reactions
- Citation
- CHEMISTRY-AN ASIAN JOURNAL, v.13, no.17, pp 2405 - 2409
- Pages
- 5
- Journal Title
- CHEMISTRY-AN ASIAN JOURNAL
- Volume
- 13
- Number
- 17
- Start Page
- 2405
- End Page
- 2409
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/802
- DOI
- 10.1002/asia.201800524
- ISSN
- 1861-4728
1861-471X
- Abstract
- A method has been developed for the synthesis of fluoroalkylated oximes, potential fluoroalkyl building-blocks for the synthesis of various organofluorine compounds, from easily available amino substrates and fluoroalkylated alkenes. tBuONO was utilized both as a diazotizing agent and as a NO radical source for the oxime synthesis in the process, and the use of a photocatalyst under visible-light irradiation increased the efficiency of the reaction. Various fluoroalkylated oximes were prepared by a tandem process of aryl radical addition to fluoroalkylated alkene and consecutive oxime generation process, albeit in moderate yields. This differentiated approach, transferring an aromatic system into an electron-deficient fluoroalkylated alkene, expands the scope of substrates where electron-poor aromatic systems could be utilized.
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Collections - College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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