Anti-Obesity Activities of Chikusetsusaponin IVa and Dolichos lablab L. Seedsopen access
- Authors
- Yin, Jun; Seo, Chang-Seob; Hwang, In Hyeok; Lee, Min Won; Song, Kwang Hoon
- Issue Date
- Sep-2018
- Publisher
- MDPI
- Keywords
- Dolichos lablab L; chikusetsusaponin IVa; triterpenoid saponin; anti-obesity; 3T3-L1 cell differentiation
- Citation
- NUTRIENTS, v.10, no.9
- Journal Title
- NUTRIENTS
- Volume
- 10
- Number
- 9
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/887
- DOI
- 10.3390/nu10091221
- ISSN
- 2072-6643
2072-6643
- Abstract
- Obesity, a condition where excess body fat accumulates to the extent, causes a negative effect on health. Previously, we reported the extract of Dolichos lablab L. (DLL-Ex) inhibited high-fat diet (HFD)-induced increases in body weight and body fat mass and ameliorated increases in body weight. In the present work, we studyed the molecular mechanism for the inhibitory effect of DLL-Ex or Chikusetsusaponin IVa (CS-IVa), as isolated from Dolichos lablab L. (DLL) seeds extract, on adipocyte differentiation. We evaluated the effect of DLL-Ex, an anti-obesity agent, and CS-IVa, an active component of DLL-Ex, on 3T3-L1 cell differentiation via Oil red O assay and Q-PCR, along with their effects on CCAAT element binding protein alpha (C/EBP), peroxisome proliferator-activated receptor gamma (PPAR), fatty acid synthase (FAS), and fatty acid-binding protein 4 (FABP4) mRNA transcriptions. FAS and FABP4 protein expression levels after exposure to CS-IVa were also tested. The results showed that DLL-Ex and CS-IVa have potent inhibitory activity on adipocyte differentiation. Therefore, DLL and CS-IVa may be developed as a functional food material to treat obesity.
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