Nano "Chocolate Waffle" for near-IR Responsive Drug Releasing System
- Authors
- Lee, Junseok; Park, Hansoo; Kim, Won Jong
- Issue Date
- Oct-2015
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- nanostructures; graphene oxide; mesoporous silica; drug delivery; photothermal materials
- Citation
- SMALL, v.11, no.39, pp 5315 - 5323
- Pages
- 9
- Journal Title
- SMALL
- Volume
- 11
- Number
- 39
- Start Page
- 5315
- End Page
- 5323
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/8999
- DOI
- 10.1002/smll.201403228
- ISSN
- 1613-6810
1613-6829
- Abstract
- A majority of the photo-responsive drug-delivery systems that are currently being studied require a complicated synthesis method. Here, we prepare a near-infrared responsive, photothermally controllable, drug-delivery carrier by a simple mixing and extraction process without the incorporation of toxic chemicals. A blend of doxorubicin (DOX), an anticancer drug, and a phase-change material (PCM) are loaded onto the mesoporous structure of silica-coated graphene oxide (GO@MS) to form a waffle-like structure, which is confirmed by various physicochemical analyses. The cytotoxicity of DOX/PCM-loaded GO@MS (DOX/PCM-GO@MS) against HeLa cells is 50 times higher than that of free DOX, and this improved activity can be attributed to the photothermal effectiveness of GO@MS. Additionally, the cytotoxicity and uptake mechanism of the PCM-based material are analyzed by flow cytometry. Taken together, our results suggest an enormous potential for spatio-temporal control in photothermally responsive drug-delivery systems.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of ICT Engineering > School of Integrative Engineering > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/8999)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.