Individual differences in novelty-seeking behavior in spontaneously hypertensive rats: Enhanced sensitivity to the reinforcing effect of methylphenidate in the high novelty-preferring subpopulation
- Authors
- dela Pena, Ike; Gonzales, Edson Luck; de la Pena, June Bryan; Kim, Bung-Nyun; Han, Doug Hyun; Shin, Chan Young; Cheong, Jae Hoon
- Issue Date
- Aug-2015
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- SHR; Novelty-seeking; Methylphenidate; ADHD; Addiction
- Citation
- JOURNAL OF NEUROSCIENCE METHODS, v.252, pp 48 - 54
- Pages
- 7
- Journal Title
- JOURNAL OF NEUROSCIENCE METHODS
- Volume
- 252
- Start Page
- 48
- End Page
- 54
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9213
- DOI
- 10.1016/j.jneumeth.2014.08.019
- ISSN
- 0165-0270
1872-678X
- Abstract
- Background: High novelty seeking has been assumed to predict vulnerability to use addictive drugs. Notably, it is also a symptom associated with attention-deficit/hyperactivity disorder (ADHD). The aim of this study was to identify whether spontaneously hypertensive rats (SHRs), putative animal models of ADHD, display individual differences in novelty-seeking behavior, and whether high novelty-seeking SHRs show enhanced sensitivity to the reinforcing effect of methylphenidate, the most commonly prescribed stimulant ADHD medication. Methods: First, we established that SHRs show higher levels of novelty-seeking behavior than their normotensive control strain, Wistar Kyoto (WKY) rats. Novelty seeking was measured in two tests: open field test in a novel test arena, and novel object preference tests. Thereafter, SHRs were classified into high responders (HR) or low responders (LR), high novelty-preferring (HNP) or low novelty-preferring (LNP) rats, based on individual scores in the two behavioral assays. Methylphenidate self-administration was assessed thereafter. Results: SHRs showed higher levels of novelty-seeking behavior than WKY rats. HR/LR and HNP/LNP subgroups were identified. HR and LR rats showed comparable rates of methylphenidate self-administration. However, HNP SHRs worked more for methylphenidate infusions than their LNP counterparts. Conclusions: We showed some evidence on inter-individual variations in novelty seeking in SHRs. Importantly, we demonstrated enhanced sensitivity of HNP SHRs to the reinforcing effect of methylphenidate, indicating a "drug-vulnerable" SHR subpopulation. These findings are important as they may provide basis for a potential screening tool to identify a subset of ADHD patients (i.e. high novelty seekers) who may be at risk for misusing/abusing methylphenidate. (C) 2014 Elsevier B.V. All rights reserved.
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