Inhibition of discoidin domain receptor 2-mediated lung cancer cells progression by gold nanoparticle-aptamer-assisted delivery of peptides containing transmembrane-juxtamembrane 1/2 domain
- Authors
- Kim, Daehwan; Yeom, Ji-Hyun; Lee, Boeun; Lee, Kangseok; Bae, Jeehyeon; Rhee, Sangmyung
- Issue Date
- Aug-2015
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Discoidin domain receptor 2; Juxtamembrane domain; DNA aptamer; Gold nanoparticle; Peptide delivery
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.464, no.2, pp 392 - 395
- Pages
- 4
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 464
- Number
- 2
- Start Page
- 392
- End Page
- 395
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9220
- DOI
- 10.1016/j.bbrc.2015.06.044
- ISSN
- 0006-291X
1090-2104
- Abstract
- The delivery of biologically functional peptides into mammalian cells can be a direct and effective method for cancer therapy and treatment of other diseases. Discoidin domain receptor 2 (DDR2) is a collagen-induced receptor tyrosine kinase recently identified as a novel therapeutic target in lung cancer. In this study, we report that peptides containing the functional domain of DDR2 can be efficiently delivered into lung malignant cancer cells via a gold nanoparticle-DNA aptamer conjugate (AuNP-Apt)-based system. Peptide delivery resulted in the abrogation of DDR2 activation triggered by collagen. Moreover, the peptide delivered by the AuNP-Apt system inhibited cancer cell proliferation and invasion mediated by DDR2 activation. Thus, these results suggest that peptide loaded onto AuNP-Apt conjugates can be used for the development of peptide-based biomedical applications for the treatment of DDR2-positive cancer. (C) 2015 Elsevier Inc. All rights reserved.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
- College of Natural Sciences > Department of Life Science > 1. Journal Articles
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