Prestroke antiplatelet agents in first-ever ischemic stroke Clinical effects
- Authors
- Jung, Jin-Man; Choi, Jungsoon; Eun, Mi-Yeon; Seo, Woo-Keun; Cho, Kyung-Hee; Yu, Sungwook; Oh, Kyungmi; Hong, Soonwoong; Park, Kwang-Yeol
- Issue Date
- Mar-2015
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Citation
- NEUROLOGY, v.84, no.11, pp 1080 - 1089
- Pages
- 10
- Journal Title
- NEUROLOGY
- Volume
- 84
- Number
- 11
- Start Page
- 1080
- End Page
- 1089
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9750
- DOI
- 10.1212/WNL.0000000000001361
- ISSN
- 0028-3878
1526-632X
- Abstract
- Objective:To investigate whether prestroke antiplatelet agent (PA) use was associated with initial stroke severity.Methods:This was a retrospective, case-control study based on data from a prospectively collected hospital-based stroke registry (Korea University Stroke Registry). A total of 3,025 patients who were admitted with a diagnosis of first-ever ischemic stroke within 5 days of symptom onset were included. Stroke severity was measured with the NIH Stroke Scale (NIHSS). NIHSS score 4 at admission was categorized as mild stroke. Patients from the PA group were matched with those from the non-PA group using estimated propensity scores at a 1:1 ratio. Stepwise multivariable logistic regression analyses were performed on patients in the matched datasets with initial mild stroke.Results:Patients' mean age was 66.3 13.0 years, and 1,850 were men (61.5%). A total of 748 patients had been taking antiplatelet agents prior to stroke onset; 644 patients (86.1%) were taking a single antiplatelet agent. Among these agents, aspirin (83.7%) was the most common. A total of 102 patients (13.6%) were taking 2 antiplatelet agents. Multivariable analysis after propensity score matching demonstrated that PA use was associated with initial mild stroke (odds ratio 1.344; 95% confidence interval 1.014-1.782).Conclusions:PA use was associated with decreased first-ever stroke severity, suggesting that it has a beneficial effect.Classification of evidence:This study provides Class II evidence that prestroke use of antiplatelet agents reduces stroke severity in patients with first-ever acute ischemic stroke.
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