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Pharmacological action of DA-9701 on the motility of feline stomach circular smooth muscle

Authors
Thanh Thao NguyenSong, Hyun JuKo, Sung KwonSohn, Uy Dong
Issue Date
Mar-2015
Publisher
GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH
Citation
PHARMAZIE, v.70, no.3, pp 183 - 192
Pages
10
Journal Title
PHARMAZIE
Volume
70
Number
3
Start Page
183
End Page
192
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9798
DOI
10.1691/ph.2015.4563
ISSN
0031-7144
Abstract
DA-9701, a new prokinetic agent for the treatment of functional dyspepsia, is formulated with Pharbitis semen and Corydalis tuber. This study wasconducted to determine the pharmacological action of DA-9701 and to identify the receptorsinvolved in DA-9701-induced contractile responsesin the feline gastric corporal, fundic and antral circular smooth muscle. Concentration-response curve to DA-9701 was established. The tissue trips were exposed to methylsergide, ketanserin, ondansetron, GR 113808, atropine and dopamine before administration ofDA-9701. The contractile force was determined before and after administration of drugs by a polygraph.DA-9701 enhanced the spontaneous contractile amplitude of antrum, corpus and fundus. However, it did not change the spontaneous contractile frequency of antrum and corpus, but concentration-dependently reduced that of fundus. In the fundus, DA-9701-induced tonic contractions were inhibited by dopamine, methylsergide, ketanserine, ondansetron or GA 113808 respectively, but not by atropine, indicating that the contractile responses are mediated by multiple receptors: 5-HT2, 5-HT3, 5-HT4, and dopamine receptors. In the corpus, DA-9701-induced contractions were blocked by atropine, dopamine or GR 113808, but not by methysergide, ketanserin or ondansetron, indicating that they are involved in receptors on both, smooth muscles and neurons: 5-HT4 and dopamine receptors. However, contractile responses to DA-9701 are mainly mediated by dopamine receptors in the antrum.These results suggest that DA-9701 has important roles in gastric accommodation by enhancing tonic activity of fundus, and in gastric emptying and gastrointestinal transit by phasic contractions of corpus and antrummediated by multiple receptors.
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