Preparation and Characterization of a Lutein Solid Dispersion to Improve Its Solubility and Stability
- Authors
- Lim, Chaemin; Kang, Jin Kook; Jung, Chan Eun; Sim, Taehoon; Her, Jaewon; Kang, Kioh; Lee, Eun Seong; Youn, Yu Seok; Choi, Han-Gon; Oh, Kyung Taek
- Issue Date
- Jun-2021
- Publisher
- Springer Science and Business Media Deutschland GmbH
- Keywords
- absorption; bioavailability; degradation; lutein; oral drug delivery; pH sensitivity; solid dispersion; stability
- Citation
- AAPS PharmSciTech, v.22, no.5, pp.1 - 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- AAPS PharmSciTech
- Volume
- 22
- Number
- 5
- Start Page
- 1
- End Page
- 9
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/105768
- DOI
- 10.1208/s12249-021-02036-4
- ISSN
- 1530-9932
- Abstract
- Lutein has been used as a dietary supplement for the treatment of eye diseases, especially age-related macular degeneration. For oral formulations, we investigated lutein stability in artificial set-ups mimicking different physiological conditions and found that lutein was degraded over time under acidic conditions. To enhance the stability of lutein upon oral intake, we developed enteric-coated lutein solid dispersions (SD) by applying a polymer, hydroxypropyl methylcellulose acetate succinate (HPMCAS-LF), through a solvent-controlled precipitation method. The SD were characterized in crystallinity, morphology, and drug entrapment. In the dissolution profile of lutein SD, a F80 formulation showed resistance toward the acidic environment under simulated gastric conditions while exhibiting a bursting drug release under simulated intestinal conditions. Our results highlight the potential use of HPMCAS-LF as an effective matrix to enhance lutein bioavailability during oral delivery and to provide novel insights into the eye-care supplement industry, with direct benefits for the health of patients. Graphical abstract: [Figure not available: see fulltext.]. © 2021, American Association of Pharmaceutical Scientists.
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