Precipitation-Mediated PEGylation of Plant-Derived Nanovesicles
- Authors
- Van Quy Nguyen; Um, Wooram; An, Jae Yoon; Joo, Hyeyeon; Choi, Young Chan; Jung, Jae Min; Choi, Ji Suk; You, Dong Gil; Cho, Yong Woo; Park, Jae Hyung
- Issue Date
- Feb-2022
- Publisher
- 한국고분자학회
- Keywords
- polyethylene glycol (PEG); extracellular vesicles; plant nanovesicles
- Citation
- Macromolecular Research, v.30, no.2, pp 85 - 89
- Pages
- 5
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Macromolecular Research
- Volume
- 30
- Number
- 2
- Start Page
- 85
- End Page
- 89
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/107975
- DOI
- 10.1007/s13233-022-0016-x
- ISSN
- 1598-5032
2092-7673
- Abstract
- Recently, plant-derived nanovesicles have attracted interest in the field of regenerative medicine because of their abundant immune-regulatory RNAs and phytochemicals with cell proliferation activity. However, the poor stability and rapid clearance of vesicles remain major challenges in their clinical applications. Herein, we report a facile method for surface modification of plant-derived nanovesicles by precipitation in the presence of poly(ethylene glycol) (PEG). We confirmed that PEGylation of nanovesicles slightly increased the particle size and zeta potential values. Importantly, this simple precipitation method produced PEGylated nanovesicles without any quantitative or qualitative loss of internal contents. When dispersed in PBS (pH 7.4), PEGylated nanovesicles did not exhibit a significant change in size for 24 h, indicating their high stability. Overall, our precipitation-based method is a useful technique for PEGylation of plant-derived nanovesicles without loss of bioactivity.
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Collections - COLLEGE OF ENGINEERING SCIENCES > DEPARTMENT OF MATERIALS SCIENCE AND CHEMICAL ENGINEERING > 1. Journal Articles
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