Neuroprotective Potential of Carnosine in Cerebrovascular Diseases
- Authors
- Neelakandan, A. R.; Bae, Ok-Nam; Majid, Arshad; Burak, Caglayan A.; Rajanikant, G. K.
- Issue Date
- Jan-2022
- Publisher
- Springer Verlag
- Keywords
- Carnosine; Ischemic stroke; Hemorrhagic stroke; Vascular dementia; Neuroprotection
- Citation
- International Journal of Peptide Research and Therapeutics, v.28, no.1, pp 1 - 12
- Pages
- 12
- Indexed
- SCIE
SCOPUS
- Journal Title
- International Journal of Peptide Research and Therapeutics
- Volume
- 28
- Number
- 1
- Start Page
- 1
- End Page
- 12
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/108035
- DOI
- 10.1007/s10989-021-10342-5
- ISSN
- 1573-3149
1573-3904
- Abstract
- The growing prevalence, the risk of disabilities, and the lack of effective causal or disease-modifying therapies make cerebrovascular disorders a serious burden. Carnosine, an evolutionarily conserved endogenous dipeptide and over-the-counter food supplement, has a wealth of evidence exhibiting potentially neuroprotective effects. It is a natural, multi-functional, non-toxic anti-glycating antioxidant found in high concentrations in human and mammalian muscle and brain tissues. The physiological presence of carnosine in the brain, ability to cross the blood-brain barrier, and evidence from in vitro, and in vivo studies all point to it as a promising neurotherapeutic agent for cerebrovascular disorders. This review is intended to provide a detailed overview of the neuroprotective role of carnosine in cerebrovascular diseases and summarize existing evidence from cell and animal studies.
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