Harnessing paper folding mechanism for reconfigurable DNA origami
- Authors
- Kim, Myoungseok; Lee, Chanseok; Jeon, Kyounghwa; Lee, Jae Young; Kim, Young-Joo; Lee, Jae Gyung; Kim, Hyunsu; Cho, Maenghyo; Kim, Do-Nyun
- Issue Date
- Jul-2023
- Publisher
- Nature Publishing Group
- Citation
- Nature, v.619, no.7968, pp 78 - 86
- Pages
- 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- Nature
- Volume
- 619
- Number
- 7968
- Start Page
- 78
- End Page
- 86
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/117764
- DOI
- 10.1038/s41586-023-06181-7
- ISSN
- 0028-0836
1476-4687
- Abstract
- The paper-folding mechanism has been widely adopted in building of reconfigurable macroscale systems because of its unique capabilities and advantages in programming variable shapes and stiffness into a structure1–5. However, it has barely been exploited in the construction of molecular-level systems owing to the lack of a suitable design principle, even though various dynamic structures based on DNA self-assembly6–9 have been developed10–23. Here we propose a method to harness the paper-folding mechanism to create reconfigurable DNA origami structures. The main idea is to build a reference, planar wireframe structure24 whose edges follow a crease pattern in paper folding so that it can be folded into various target shapes. We realized several paper-like folding and unfolding patterns using DNA strand displacement25 with high yield. Orthogonal folding, repeatable folding and unfolding, folding-based microRNA detection and fluorescence signal control were demonstrated. Stimuli-responsive folding and unfolding triggered by pH or light-source change were also possible. Moreover, by employing hierarchical assembly26 we could expand the design space and complexity of the paper-folding mechanism in a highly programmable manner. Because of its high programmability and scalability, we expect that the proposed paper-folding-based reconfiguration method will advance the development of complex molecular systems. © 2023, The Author(s), under exclusive licence to Springer Nature Limited.
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